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服务
产品  
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Substance P
| 名称
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Substance P
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| 别名
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| 序列（单字母缩写）
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RPKPQQFFGLM-NH2
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| 序列（三字母缩写）
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{ARG}{PRO}{LYS}{PRO}{GLN}{GLN}{PHE}{PHE}{GLY}{LEU}{MET}-NH2
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| C-端
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NH2
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| 基本描述
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Substance P is found in the gut and in the brain. It is responsible for a number of excitatory effects on both central and peripheral neurons. Substance P contracts smooth muscle, constricts bronchioles, and increases capillary permeability. When released from afferent nerves, Substance P causes a neurogenic inflammatory response, including mast cell degranulation. It's an NK-1 agonist; a potent vasodilator and hypotensive agent; it induces salivation; it's a putative neurotransmitter in sensory (pain) afferents.
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| 溶解度
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Soluble in water (1 mg/ml)
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| 分子量
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1347.630
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| 化学式
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C63H98N18O13S1
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| 纯度
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> 95%
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| 存储条件
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Store the peptide at -20°C. Keep container tightly closed.
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| 注释
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HIV-I TAT Protein Peptide
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| Documents
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| Figures
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| Reference
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Wick EC, et al. Transient receptor potential vanilloid 1, et al. calcitonin gene-related peptide, and substance P mediate nociception in acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. May 2006;290(5):G959-969.
Allen JW, et al. Safety Evaluation of Intrathecal Substance P-Saporin, a Targeted Neurotoxin, in Dogs. Toxicol Sci. May 2006;91(1):286-298.
Lindenburg PW., et al. On-line large-volume electroextraction coupled to liquid chromatography–mass spectrometry to improve detection of peptides. J Chromatogr A. 2012 Aug;124917-24.
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