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服务
产品  
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 Β-Amyloid (25-35)
| 名称
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Β-Amyloid (25-35)
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| 别名
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βAmyloid; b-Amyloid; bAmyloid; beta-Amyloid; betaAmyloid
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| 序列（单字母缩写）
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GSNKGAIIGLM
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| 序列（三字母缩写）
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{GLY}{SER}{ASN}{LYS}{GLY}{ALA}{ILE}{ILE}{GLY}{LEU}{MET}
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| 基本描述
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Beta-amyloid protein (Abeta), a major component of senile plaques of Alzheimer's disease (AD) in the brain, causes elevation of the intracellular free Ca2+ level and the production of robust free radicals. Beta-amyloid 25-35 induced apoptosis, characterized by decreased cell viability, neuronal DNA condensation, and fragmentation, is associated with an increase in intracellular free Ca2+ level, the accumulation of reactive oxygen species (ROS), and the activation of caspase-3. All of these effects induced by beta-amyloid 25-35 are reversed by genistein.
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| 溶解度
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The peptide is soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
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| 分子量
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1060.270
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| 化学式
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C45H81N13O14S1
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| 纯度
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> 95%
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| 存储条件
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Store the peptide at -20°C
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| 注释
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| Documents
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| Figures
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| Reference
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Fang F, Liu GT. Protective effects of compound FLZ on beta-amyloid peptide-(25-35)-induced mouse hippocampal injury and learning and memory impairment. Acta. Pharmacol. Sin. Jun 2006; 27(6): 651-658.
Mantha AK, et al. Neuroprotective role of neurokinin B (NKB) on beta-amyloid (25-35) induced toxicity in aging rat brain synaptosomes: involvement in oxidative stress and excitotoxicity. Biogerontology. Feb 2006; 7(1): 1-17.
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