| Name
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A-779
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| Other Name
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|
| Sequence (Single letter abbreviations)
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DRVYIH{D-Ala}
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| Sequence（Three letter abbreviations）
|
{ASP}{ARG}{VAL}{TYR}{ILE}{HIS}{d-ALA}
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| Basic description
|
A-779 is a potent and selective Ang (1-7) antagonist. A-779 antagonizes several actions of Ang (1-7), including A-779's antidiurectic effect and the changes in MAP produced by Ang (1-7) microinjection into the dorsomedial or ventrolateral medulla.
|
| The molecular weight
|
873.000
|
| Chemical formula
|
C39H60N12O11
|
| The purity
|
> 95%
|
| Storage conditions
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Store at -20°C.
|
| Annotation
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| Documents
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| Figures
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| Reference
|
Santos RA, et al. Impairment of in vitro and in vivo heart function in angiotensin-(1-7) receptor MAS knockout mice. Hypertension. May 2006; 47(5): 996-1002.
Iwata M, et al. Angiotensin-(1-7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects. Am J Physiol Heart Circ Physiol. Dec 2005; 289(6): H2356-H2363.
Gonzalez-Villalobos R, et al. Megalin binds and internalizes angiotensin-(1-7). Am J Physiol Renal Physiol. May 2006; 290(5): F1270-F1275.
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A-779
