| Name
|
Apamin
|
| Other Name
|
|
| Sequence (Single letter abbreviations)
|
CNCKAPETALCARRCQQH-NH2
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| Sequence（Three letter abbreviations）
|
{CYS}{ASN}{CYS}{LYS}{ALA}{PRO}{GLU}{THR}{ALA}{LEU}{CYS}{ALA}{ARG}{ARG}{CYS}{GLN}{GLN}{HIS}-NH2
|
| C-port
|
NH2
|
| Chemical bridge
|
Disulfide Bridge Cys1-Cys11 and Cys3-Cys15
|
| Basic description
|
Apamin, a bee venom polypeptide, blocks specifically the Ca2+-dependent K+ channels that are not blocked by tetraethylammonium chloride in muscle cells. Apamin is a ly specific compound that tightly binds to the Ca2+ slow channels, thus blocking the slow APs in heart muscle. In addition, quinidine antagonizes the apamin binding on the slow APs.
|
| The molecular weight
|
2027.300
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| Chemical formula
|
C79H131N31O24S4
|
| The purity
|
> 95%
|
| Storage conditions
|
Store at -20°C. Keep tightly closed. Store in a cool dry place.
|
| Annotation
|
Originally isolated from Apis mellifera. A small conductance Ca2+-activated K+ channel blocker.
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| Documents
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|
| Figures
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|
| Reference
|
Kato M, et al. SK Channel Blocker Apamin Inhibits Slow Afterhyperpolarization Currents in Rat Gonadotropin-Releasing Hormone Neurones. J. Physiol. 2006 Apr.
Deschaux O, Bizot JC. Apamin produces selective improvements of learning in rats. Neurosci. Lett. Sep 2005; 386(1): 5-8.
Mpari B, et al. Differential effects of two blockers of small conductance Ca2+-activated K+ channels, apamin and lei-Dab7, on learning and memory in rats. J. Integr. Neurosci. Sep 2005; 4(3): 381-396.
Dana V. Skarra., etc. CyPPA, a positive modulator of small-conductance Ca2+-activated K+ channels, inhibits phasic uterine contractions and delays preterm birth in mice. Am J Physiol Cell Physio
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Apamin
