| Name
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Bombesin
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| Other Name
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| Sequence (Single letter abbreviations)
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| Sequence（Three letter abbreviations）
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GLP-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-HIS-LEU-MET-NH2
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| C-port
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NH2
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| Basic description
|
Bombesin is a 14 amino acid peptide originally isolated from the skin of a frog. Bombesin has two known homologues in mammals called neuromedin B and gastrin releasing peptide. Bombesin works on the gastrointestinal tract neuroendocrine hormone and bombesin stimulates gastrin release from G cells. Bombesin activates three different G-protein coupled receptors known as BBR1 2 and 3. Bombesin also activates these receptors in the brain. Together with cholecystokinin bombesin is the second major source of negative feedback signals that stop eating behavior.
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| Solubility
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20 mg/ml CH3COOH 0.05 M clear, colorless
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| The molecular weight
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1619.900
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| Chemical formula
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C71H110N24O18S1
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| The purity
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> 95%
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| Storage conditions
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Store at -20°C
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| Annotation
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| Documents
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| Figures
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| Reference
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Xiao D, et al. Bombesin regulates cyclin D1 expression through the early growth response protein Egr-1 in prostate cancer cells. Cancer Res. Nov 2005; 65(21): 9934-9942.
Li L, Wice BM. et al. Bombesin and nutrients independently and additively regulate hormone release from GIP/Ins cells. Am. J. Physiol. Endocrinol. Metab. Jan 2005; 288(1): E208-215.
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Bombesin
