| Name
|
CLIP (86-100)
|
| Other Name
|
|
| Sequence (Single letter abbreviations)
|
PVSKMRMATPLLMQA
|
| Sequence（Three letter abbreviations）
|
{Pro}{Val}{Ser}{Lys}{Met}{Arg}{Met}{Ala}{Thr}{Pro}{Leu}{Leu}{Met}{Gln}{Ala}
|
| Basic description
|
This is amino acids 86 to 100 fragment of class II-associated invariant chain peptide called CLIP. The major histocompatibility complex class II molecule displays peptide fragments of foreign proteins to trigger a defensive reaction from the immune system. Before insertion of the foreign peptides into the binding groove, a place-holding peptide CLIP is removed. This is accomplished by the molecule DM, which is shown to increase the dissociation rate of a CLIP peptide from class II.
|
| The molecular weight
|
1674.100
|
| Chemical formula
|
C72H128N20O19S3
|
| The purity
|
> 95%
|
| Storage conditions
|
Store at -20°C. Keep tightly closed. Store in a cool dry place.
|
| Documents
|
|
| Figures
|
|
| Reference
|
Chen S., et al. Structure-Based Design of Altered MHC Class II–Restricted Peptide Ligands with Heterogeneous Immunogenicity. J Immunol. 2013 Nov;191(10):5097-106.
|
CLIP (86-100)
