| Name
|
Corticotropin Releasing Factor, Ovine
|
| Other Name
|
CRFCorticotropin-releasing hormone (CRH)
|
| Sequence (Single letter abbreviations)
|
SQEPPISLDLTFHLLREVLEMTKADQLAQQAHSNRKLLDIA-NH2
|
| Sequence（Three letter abbreviations）
|
{SER}{GLN}{GLU}{PRO}{PRO}{ILE}{SER}{LEU}{ASP}{LEU}{THR}{PHE}{HIS}{LEU}{LEU}{ARG}{GLU}{VAL}{LEU}{GLU}{MET}{THR}{LYS}{ALA}{ASP}{GLN}{LEU}{ALA}{GLN}{GLN}{ALA}{HIS}{SER}{ASN}{ARG}{LYS}{LEU}{LEU}{ASP}{ILE}{ALA}-NH2
|
| C-port
|
NH2
|
| Basic description
|
Corticotropin Releasing Factor (CRF) is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. Corticotropin Releasing Factor is also a neurotransitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.
|
| Solubility
|
Insoluble in water. Dissolve peptide in 60% Acetonitrile with 0.1% TFA solution followed by water or desired buffer.
|
| The molecular weight
|
4670.310
|
| Chemical formula
|
C205H339N59O63S1
|
| The purity
|
> 95%
|
| Storage conditions
|
Store at -20°C. Keep tightly closed. Store with desiccant.
|
| Annotation
|
Corticotropin Releasing Factor (CRF) analog used to prepare iodinated CRF for receptor studies and immunoassay.
|
| Documents
|
|
| Figures
|
|
| Reference
|
Adinoff B, et al. Dissection of hypothalamic-pituitary-adrenal axis pathology in 1-month-abstinent alcohol-dependent men, part 2: response to ovine corticotropin-releasing factor and naloxone. Alcohol. Clin. Exp. Res. Apr 2005; 29(4): 528-537.
|
Corticotropin Releasing Factor, Ovine
