| Name
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g3-c12
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| Other Name
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| Sequence (Single letter abbreviations)
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ANTPCGPYTHDCPVKR
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| Sequence（Three letter abbreviations）
|
{Ala}{Asn}{Thr}{Pro}{Cys}{Gly}{Pro}{Tyr}{Thr}{His}{Asp}{Cys}{Pro}{Val}{Lys}{Arg}
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| Basic description
|
Galectin-3 is a member of the galectin family of beta-galactoside-binding animal lectins. Galectin-3 is overexpressed in a wide range of neoplasms and is associated with tumor growth and metastases. Given this fact, radiolabeled galectin-3-targeting molecules may be useful for the noninvasive imaging of tumors expressing galectin-3, as well as for targeted radionuclide therapy. In this study, the tumor cell-targeting and SPECT properties of a galectin-3-avid peptide identified from bacteriophage display were evaluated in human breast carcinoma cells and in human breast tumor-bearing mice. The galectin-3-avid peptide G3-C12 (ANTPCGPYTHDCPVKR) was synthesized with a Gly-Ser-Gly (GSG) linker at the amino terminus.
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| The molecular weight
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1758.980
|
| Chemical formula
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C74H115N23O23S2
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| The purity
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> 95%
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| Storage conditions
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Store at -20°C
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| Annotation
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| Documents
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| Figures
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| Reference
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Kumar SR,J Nucl Med. 2008 May;49(5):796-803. Epub 2008 Apr 15.
Newton-Northup JR., et al. Inhibition of metastatic tumor formation in vivo by a bacteriophage display-derived galectin-3 targeting peptide. Clin Exp Metastasis. 2013 Apr;30(2):119-132.
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g3-c12
