| Name
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Galantide
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| Other Name
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| Sequence (Single letter abbreviations)
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GWTLNSAGYLLGPQQFFGLM-NH2
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| Sequence（Three letter abbreviations）
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{GLY}{TRP}{THR}{LEU}{ASN}{SER}{ALA}{GLY}{TYR}{LEU}{LEU}{GLY}{PRO}{GLN}{GLN}{PHE}{PHE}{GLY}{LEU}{MET}
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| C-port
|
NH2
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| Basic description
|
The galanin-antagonist galantide, a chimeric peptide obtained from amino acids 1-13 of galanin attached to the C-terminal fragment of bradykinin, has been found to improve social memory in 'social recognition' test when i.c.v. administered at doses varying from 6-6000nmoles. Galantide causes widespread antagonism to the action of galanin and reversibly blocks the neuronal actions of galanin in a dose-dependent manner. It inhibits the release of acetylcholine, reduces the response to galanin in the hypothalamus, and blocks the effect of galanin on glucose-induced insulin secretion.
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| Solubility
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Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
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| The molecular weight
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2199.600
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| Chemical formula
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C104H151N25O26S1
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| The purity
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> 95%
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| Storage conditions
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store at -20°C. Keep tightly closed. Store in a cool dry place.
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| Annotation
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| Documents
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| Figures
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| Reference
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Galantide
