| Name
|
InsB 9-23
|
| Other Name
|
|
| Sequence (Single letter abbreviations)
|
SHLVEALYLVCGERG
|
| Sequence（Three letter abbreviations）
|
{Ser}{His}{Leu}{Val}{Glu}{Ala}{Leu}{Tyr}{Leu}{Val}{Cys}{Gly}{Glu}{Arg}{Gly}
|
| Basic description
|
This insulin B-chain peptide binds to a class II histocompatibility complex (MHC) allele called I-Ag7. A number of autoimmune diseases has been linked to class II proteins encoded by the MHC. Type 1 diabetes, or insulin-dependent diabetes mellitus, is a T cell-mediated disease that results in autoimmune destruction of pancreatic ß cells to hyperglycemia. This insulin B peptide may be a self-antigen candidate that could initiate the disease. Immunization with this peptide in mice led to autoantibodies and insulitis.
|
| The molecular weight
|
1645.900
|
| Chemical formula
|
C72H116N20O22S1
|
| The purity
|
> 95%
|
| Storage conditions
|
Stored at -20°C.
|
| Annotation
|
|
| Documents
|
|
| Figures
|
|
| Reference
|
Devendra D,Diabetes. 2005 Sep;54(9):2549-56.
|
InsB 9-23
