| Name
|
Men 10376
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| Other Name
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Neurokinin-2 receptor antagonist
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| Sequence (Single letter abbreviations)
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DYWVWWK-NH2
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| Sequence（Three letter abbreviations）
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{ASP}{TYR}{d-TRP}{VAL}{d-TRP}{d-TRP}{LYS}-NH2
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| C-port
|
NH2
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| Basic description
|
Men 10376 is a potent and selective NK2 tachykinin receptor antagonist. MEN 10376 was devoid of significant agonist activity at i.v. doses (1-3 mumol/kg) which selectively antagonized the effects of an NK-2 agonist [beta-Ala8]-neurokinin A(4-10) (bladder contraction in rats, bronchoconstriction in guinea pigs) without affecting the response to an NK-1 agonist [Sar9]-substance P sulfone (hypotension, salivation and bladder contraction in rats, bronchoconstriction in guinea pigs).
|
| The molecular weight
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1081.220
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| Chemical formula
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C57H68N12O10
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| The purity
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> 95%
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| Storage conditions
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Store at -20°C. Keep tightly closed.
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| Annotation
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| Documents
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| Figures
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| Reference
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Men 10376
