| Name
|
PAR-1 Agonist Peptide
|
| Other Name
|
|
| Sequence (Single letter abbreviations)
|
SFLLRN
|
| Sequence（Three letter abbreviations）
|
{Ser}{Phe}{Leu}{Leu}{Arg}{Asn}
|
| Basic description
|
This hexapeptide corresponding to residues 42-47 of the thrombin receptor has been shown to be a thrombin receptor activator. It caused half-maximal platelet aggregation at approx. 0.8 uM and was 5 times more potent than the parent peptide H-8105. In addition, SFLLRN is effective in causing tyrosine phosphorylation, inhibition of cAMP formation, and an increase in cytosolic Ca2+.
|
| The molecular weight
|
748.870
|
| Chemical formula
|
C34H56N10O9
|
| The purity
|
> 95%
|
| Storage conditions
|
Store at -20°C.
|
| Annotation
|
|
| Documents
|
|
| Figures
|
|
| Reference
|
Simmons Sarah., et al. Thrombin induces release of proinflammatory chemokines interleukin-8 and interferon-c-induced protein-10 from cultured human fetal astrocytes. Neuroreport. 2013 Jan;24(1):36-40.
|
PAR-1 Agonist Peptide
