| Name
|
SHU 9119
|
| Other Name
|
|
| Sequence (Single letter abbreviations)
|
|
| Sequence（Three letter abbreviations）
|
Ac-Nle-cyclo[Asp-His-D-Nal(2')-Arg-Trp-Lys]-NH2
|
| C-port
|
Amidation
|
| Chemical bridge
|
Asp2-Lys7
|
| Basic description
|
The efficacy and specificity of SHU-9119 as an MC3/MC4 receptor antagonist in the rat was first validated in vitro and in vivo. In vitro, in heterologous cells expressing either rat MC3-R or MC4-R, the major MCR subtypes expressed in brain, SHU-9119 showed no intrinsic agonism.
|
| solubility
|
Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
|
| The molecular weight
|
1074.230
|
| Chemical formula
|
C54H71N15O9
|
| The purity
|
> 95%
|
| Storage conditions
|
Storage at -20°C. Keep tightly closed.
|
| N-port
|
Acetylation
|
| Annotation
|
Antagonist of rat MC3 and mouse MC4 receptors.
|
| Documents
|
|
| Figures
|
|
| Reference
|
|
SHU 9119
