| Name
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Substance P (1-9)
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| Other Name
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| Sequence (Single letter abbreviations)
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RPKPQQFFG
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| Sequence（Three letter abbreviations）
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{ARG}{PRO}{LYS}{PRO}{GLN}{GLN}{PHE}{PHE}{GLY}
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| Basic description
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Subtance P is responsible for a number of excitatory effects on both central and peripheral neurons. Substance P contracts smooth muscle, constricts bronchioles and increases capillary permeability. When released from afferent nerves, Substance P causes a neurogenic inflammatory response, including mast cell degranulation. NK-1 agonist; potent vasodilator and hypotensive agent; induces salivation; putative neurotransmitter in sensory (pain) afferents. Substance P(1-9) is a fragment of Subtance P. Accumulating evidence shows that N- and C-terminal substance P fragments have significant biological activity. Substance P(1-9) has been reported to be major substance P metabolites in rat striatum and it has modulatory effects similar to substance P.
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| The molecular weight
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1104.300
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| Chemical formula
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C52H77N15O12
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| The purity
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> 95%
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| Storage conditions
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Store at -20°C。
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| Annotation
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| Documents
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| Figures
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| Reference
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Lai JP, et al. Real-time reverse transcription-PCR quantitation of substance P receptor (NK-1R) mRNA. Clin. Diagn. Lab. Immunol. Apr 2005; 12(4): 537-541.
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Substance P (1-9)
