| Name
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TAT
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| Other Name
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| Sequence (Single letter abbreviations)
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YGRKKRRQRRR-NH2
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| Sequence（Three letter abbreviations）
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{TYR}{GLY}{ARG}{LYS}{LYS}{ARG}{ARG}{GLN}{ARG}{ARG}{ARG}-NH2
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| C-port
|
NH2
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| Basic description
|
TaT is a transcriptional transactivator protein that binds to a regulatory element in the HIV-1 long terminal repeat. By recruiting P-TEFb to TAR, TaT promotes transcription of viral mRNA. This arginine-rich TAT peptide penetrates plasma membrane directly, but not through endocytosis. TaT has similar immunosuppressive effects as transforming growth factor-beta (TGF beta) and both inhibit lymphocyte proliferation.
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| The molecular weight
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1558.850
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| Chemical formula
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C64H119N33O13
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| The purity
|
> 95%
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| Storage conditions
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Store at -20°C. Keep tightly closed. Store in a cool dry place.
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| Annotation
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| Documents
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| Figures
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| Reference
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Kittiworakarn J, et al. HIV-1 Tat raises an adjuvant-free humoral immune response controlled by its core region and its ability to form cysteine-mediated oligomers. J. Biol. Chem. Feb 2006; 281(6): 3105-3115.
Mondal D, et al. The HIV-1 Tat protein selectively enhances CXCR4 and inhibits CCR5 expression in megakaryocytic K562 cells. Exp. Biol. Med.(Maywood). Oct 2005; 230(9): 631-644.
Hoque M, et al. Granulin and granulin repeats interact with the Tat.P-TEFb complex and inhibit Tat transactivation. J. Biol. Chem. Apr 2005; 280(14): 13648-13657.
Sarah M. Wilson., etc. Inhibition Of Transmitter Release And Attenuation Of Anti-Retroviral-Associated And Tibial Nerve Injury-Related Painful Peripheral Neuropathy By Novel Synthetic Ca2+ Channel Peptides. J Biol Ch
Sunavala-Dossabhoy G., etc. TAT-mediated delivery of tousled protein to salivary glands protects against radiation-induced hypofunction. Int J Radiat Oncol Biol Phys. 2012 Sep;84(1):257-65.
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TAT
