| Name
|
Β-Amyloid (1-42), Human
|
| Other Name
|
|
| Sequence (Single letter abbreviations)
|
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
|
| Sequence（Three letter abbreviations）
|
{ASP}{ALA}{GLU}{PHE}{ARG}{HIS}{ASP}{SER}{GLY}{TYR}{GLU}{VAL}{HIS}{HIS}{GLN}{LYS}{LEU}{VAL}{PHE}{PHE}{ALA}{GLU}{ASP}{VAL}{GLY}{SER} {ASN}{LYS}{GLY}{ALA}{ILE}{ILE}{GLY}{LEU}{MET}{VAL}{GLY}{GLY}{VAL}{VAL}{ILE}{ALA}
|
| Basic description
|
This peptide is well suited to the quantitative determination of A 42 peptide. Alzheimer’s disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major protein component of these plaques is beta amyloid peptide (A), a 40- to 43- amino-acid peptide cleaved from amyloid precursor protein by secretase (BACE) and a putative (gamma) secretase. Increased release of the ‘longer forms’ of A peptide, A 42 and A 43, which have a greater tendency to aggregate than A 40, occurs in individuals expressing certain genetic mutations, expressing certain ApoE alleles or may other, still undiscovered factors. |
| Solubility
|
Soluble in water
|
| The molecular weight
|
4514.100
|
| Chemical formula
|
C203H311N55O60S1
|
| The purity
|
> 95%
|
| Storage conditions
|
Store at -20°C
|
| Documents
|
|
| Reference
|
Ambroggio EE, et al. Surface behavior and lipid interaction of Alzheimer beta-amyloid peptide 1-42: a membrane-disrupting peptide. Biophys J. Apr 2005; 88(4): 2706-2713.
Mathew A., etc. Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer's disease. PLoS One. 2012 Mar;7(3):e32616.
R Banerjee. etc. Effect of Curcumin on the metal ion induced fibrillization of Amyloid-β peptide. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Sep;
Anila Mathew etc. Amyloid-Binding Aptamer Conjugated Curcumin-PLGA Nanoparticle for Potential Use in Alzheimer’s Disease. BioNanoScience. 2012 Jun; 2 (2); 83-93.
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Β-Amyloid (1-42), Human
