| Name
|
Β-Melanocyte Stimulating Hormone (MSH), Human
|
| Other Name
|
beta melanocyte stimulating hormoneβ-MSH, human
|
| Sequence (Single letter abbreviations)
|
AEKKDEGPYRMEHFRWGSPPKD
|
| Sequence（Three letter abbreviations）
|
{ALA}{GLU}{LYS}{LYS}{ASP}{GLU}{GLY}{PRO}{TYR}{ARG}{MET}{GLU}{HIS}{PHE}{ARG}{TRP}{GLY}{SER}{PRO}{PRO}{LYS}{ASP}
|
| Basic description
|
Alpha-MSH (melanocyte stimulating hormone) has generally been assumed to be the endogenous ligand acting at the melanocortin-4 receptor (MC4-R), activation of which in the hypothalamus leads to reduced feeding. However, beta-MSH is also capable of activating MC4-R and inhibiting feeding. The researchers found that obese children are more likely to carry a rare variant of so-called beta-melanocyte-stimulating hormone (beta-MSH) than children of normal weight.
|
| The molecular weight
|
2661.000
|
| Chemical formula
|
C118H174N34O35S1
|
| The purity
|
> 95%
|
| Storage conditions
|
Store the peptide at -20°C. Keep container tightly closed. Store in a cool dry place.
|
| Annotation
|
|
| Documents
|
|
| Figures
|
|
| Reference
|
Spencer JD, et al. A novel mechanism in control of human pigmentation by {beta}-melanocyte-stimulating hormone and 7-tetrahydrobiopterin. J.Endocrinol. Nov 2005; 187(2): 293-302.
Leder EH, Silverstein JT. The pro-opiomelanocortin genes in rainbow trout (Oncorhynchus mykiss): duplications, splice variants, and differential expression. J.Endocrinol. Feb 2006; 188(2): 355-363.
Hinney A, et al. Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from Germany. J.Clin.Endocrinol.Metab. May 2006; 91(5): 1761-1769.
|
Β-Melanocyte Stimulating Hormone (MSH), Human
