| Name
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[Nle11]-Substance P
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| Other Name
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| Sequence (Single letter abbreviations)
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RPKPQQFFGL-Nle-NH2
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| Sequence（Three letter abbreviations）
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{ARG}{PRO}{LYS}{PRO}{GLN}{GLN}{PHE}{PHE}{GLY}{LEU}{NLE}-NH2
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| C-port
|
NH2
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| Basic description
|
Substance P was found in the gut as well as in the brain. It is responsible for a number of excitatory effects on both central and peripheral neurons. Substance P contracts smooth muscle, constricts bronchioles and increases capillary permeability. When released from afferent nerves, Substance P causes a neurogenic inflammatory response, including mast cell degranulation. NK-1 agonist; potent vasodilator and hypotensive agent; induces salivation; putative neurotransmitter in sensory (pain) afferents. [Nle11]-Substance P is a Substance P analog that avoids methionine oxidation problems.
|
| The molecular weight
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1329.590
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| Chemical formula
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C64H100N18O13
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| The purity
|
> 95%
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| Storage conditions
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Store at -20°C. Keep tightly closed. Store in a cool dry place.
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| Annotation
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| Documents
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| Figures
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| Reference
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Wick EC, et al. Transient receptor potential vanilloid 1, calcitonin gene-related peptide, and substance P mediate nociception in acute pancreatitis. Am. J. Physiol. Gastrointest Liver Physiol. May 2006; 290(5): G959-969.
Rohleder N, et al. No response of plasma substance P, but delayed increase of interleukin-1 receptor antagonist to acute psychosocial stress. Life Sci. May 2006; 78(26): 3082-3089.
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[Nle11]-Substance P
