| Name
|
[Sar9]-Substance P
|
| Other Name
|
rNK1-specific agonist
|
| Sequence (Single letter abbreviations)
|
|
| Sequence（Three letter abbreviations）
|
{ARG}{PRO}{LYS}{PRO}{GLN}{GLN}{PHE}{PHE}{SAR}{LEU}{MET}-NH2
|
| C-port
|
NH2
|
| Basic description
|
The neuropeptide substance P(SP) is a major mediator of neurogenic inflammation and immunomodulatory activities within the central and peripheral nervous system. [Sar9]-Substance P is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP.
|
| Solubility
|
Other solvents: Insoluble in ether & benzene.
|
| The molecular weight
|
1361.660
|
| Chemical formula
|
C64H100N18O13S
|
| The purity
|
> 95%
|
| Storage conditions
|
Store at -20°C. Keep tightly closed. Store in a cool dry place.
|
| Annotation
|
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| Documents
|
|
| Figures
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| Reference
|
Patte-Mensah C, et al. Substance P inhibits progesterone conversion to neuroactive metabolites in spinal sensory circuit: a potential component of nociception. Proc. Natl. Acad. Sci. U.S.A. Jun 2005; 102(25): 9044-9049.
|
[Sar9]-Substance P
