| Name
|
[Lys(Ac)373]-p53 (368-393), p53 K373(Ac), biotin-labeled, human
|
| Code
|
|
| The alias
|
[Lys(Ac)373]-p53 (368-393), p53 K373(Ac), biotin-labeled, human
|
| Sequence (single letter abbreviation)
|
Biotin-KGGHLKSK-K(Ac)-GQSTSRHKKLMFKTEGPDSD-NH2
|
| Sequence (three-letter abbreviation)
|
Biotin-Lys-Gly-Gly-His-Leu-Lys-Ser-Lys-Lys(Ac)-Gly-Gln-Ser-Thr-Ser-Arg-His-Lys-Lys-Leu-Met-Phe-Lys-Thr-Glu-Gly-Pro-Asp-Ser-Asp-NH2(trifluoroacetate salt)
|
| A basic description
|
This is a biotin-labeled and amidated peptide derived from residues 368-393 of human p53 tumor suppressor protein with acetylation at Lys373 and additional KGW residues on its N-terminus. Activated p53 functions to induce cell cycle arrest and apoptosis in response to signals such as DNA damage. Acetylation of p53 reduces ubiquitination by MDM2 and increases p53 half-life in vivo.
|
| solubility
|
|
| The molecular weight
|
3481
|
| Chemical formula
|
|
| The purity
|
80%，90%，95%，98%，99%
|
| Weight
|
1mg,5mg,10mg,50mg,100mg,1g
|
| Storage conditions
|
Store at -20°C. Keep tightly closed. Store in a cool dry place.
|
| Annotation
|
|
| Documents
|
|
| Figures
|
|
| Reference
|
Kanovsky, M. et al. Proc Natl Acad Sci 98, 12438 (2001)
|
| The C-terminal
|
|
| The N-terminal
|
|
| Chemical bridge
|
|