| Name
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[Lys(Me2)370]-p53 (361-380); p53K370Me2
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| Code
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| The alias
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[Lys(Me2)370]-p53 (361-380); p53K370Me2
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| Sequence (single letter abbreviation)
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GSRAHSSHL-K(Me2)-SKKGQSTSRH
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| Sequence (three-letter abbreviation)
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H-Gly-Ser-Arg-Ala-His-Ser-Ser-His-Leu-Lys(Me2)-Ser-Lys-Lys-Gly-Gln-Ser-Thr-Ser-Arg-His-OH (trifluoroacetate salt)
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| A basic description
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This is a biotin-labeled and amidated peptide derived from residues 368-393 of human p53 tumor suppressor protein with dimethylation at Lys372 and additional KGW residues on its N-terminus. Methylation at Lys372 activates p53 and induces upregulation of target gene p21. Methylation at Lys372 also inhibits Lys370 methylation by interfering with Smyd2, a lysine methyltransferase, and p53 interaction. Lys 370 methylation reduces p53 transcriptional targets.
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| solubility
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| The molecular weight
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2204.4
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| Chemical formula
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| The purity
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80%，90%，95%，98%，99%
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| Weight
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1mg,5mg,10mg,50mg,100mg,1g
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| Storage conditions
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Store at -20°C. Keep tightly closed. Store in a cool dry place.
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| Annotation
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| Documents
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| Figures
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| Reference
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Egorova, K. Biochem 75, 535 (2010)
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| The C-terminal
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| The N-terminal
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| Chemical bridge
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