| Name
|
Apopain Substrate
|
| Code
|
[169332-61-0]
|
| The alias
|
Apopain Substrate
|
| Sequence (single letter abbreviation)
|
Ac-DEVD-AMC
|
| Sequence (three-letter abbreviation)
|
Ac-Asp-Glu-Val-Asp-AMC
|
| A basic description
|
Potent inhibitor for the poly(ADP-ribose) polymerase (PARP) cleavage by caspase-3 (IC50=0.2 nM). PARP cleavage occurs at the onset of apoptosis. This peptide aldehyde is useful in attenuating apoptotic events in vitro (IC50 = 10 nM).
|
| solubility
|
|
| The molecular weight
|
675.7
|
| Chemical formula
|
C30H37N5O13
|
| The purity
|
80%，90%，95%，98%，99%
|
| Weight
|
1mg,5mg,10mg,50mg,100mg,1g
|
| Storage conditions
|
Store at -20°C. Keep tightly closed. Store in a cool dry place.
|
| Annotation
|
|
| Documents
|
|
| Figures
|
|
| Reference
|
D.W. Nicholson, Nature, 376 (1995)
J. Xiang et al., Proc. Natl. Acad. Sci. USA, 93, 14559 (1996)
|
| The C-terminal
|
|
| The N-terminal
|
|
| Chemical bridge
|
|