Catalog peptides

Name ω-Conotoxin GVIA|omega-ConoGVIAn GVIA
Code [106375-28-4]
The alias ω-Conotoxin GVIA|omega-ConoGVIAn GVIA
Sequence (single letter abbreviation) CKS(Hyp)GSSCS(Hyp)TSYNCCRSCN(Hyp)YTKRCY-NH2(Disulfide bridges: Cys1-Cys16, Cys8-Cys19, Cys15-Cys26)
Sequence (three-letter abbreviation) H-Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2?(trifluoroacetate salt)(Disulfide bridges: Cys1-Cys16, Cys8-Cys19, Cys15-Cys26)
A basic description Reversible N-type Ca2+ Channel Blocker W-Conotoxin MVIIA, originally isolated from the venom of the fish-hunting cone snail Conus magus, is a blocker of voltage-sensitve Ca2+ channels in neurons. It has been used to identify different Ca2+ channel subtypes in amphibian brain.
solubility
The molecular weight 3037.39
Chemical formula C120H182N38O43S6
The purity 80%，90%，95%，98%，99%
Weight 1mg,5mg,10mg,50mg,100mg,1g
Storage conditions Store at -20°C. Keep tightly closed. Store in a cool dry place.
Annotation
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Reference Rivier, J. et al. J. Biol. Chem. 262, 1194 (1987) Lampe, RA. et al. Biochem. 32, 3255 (1993) Wright, C. and JA. Angus, J. Cardiovasc. Pharmacol. 30, 392 (1997) Serone, A. and JA. Angus, Br. J. Pharmacol. 127, 927 (1999). B.M. Olivera, J.M. Mclntosh, L.J. Cruz, F.A. Luque, and W.R. Gray, Biochemistry, 23, 5087 (1984). (Original) Y. Nishiuchi, K. Kumagaye, Y. Noda, T.X. Watanabe, and S. Sakakibara, Biopolymers, 25, S61 (1986). (Chem. Synthesis and S-S Bond) B.M.Olivera et al., Biochemistry, 23, 5087 (1984) B.M.Olivera et al., Biochemistry, 26, 2086 (1987) J.Rivier et al., J. Biol. Chem., 262, 1194 (1987) D.R.Hillyard et al., Neuron, 9, 69 (1992) K.Sato et al., Biochem. Biophys. Res. Commun., 194, 1292 (1993) J.R.Abbott and M.J.Litzinger, Int. J. Devl Neurosci., 12, 43 (1994)
The C-terminal
The N-terminal
Chemical bridge (Disulfide bridges: Cys1-Cys16, Cys8-Cys19, Cys15-Cys26)

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